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  • Viruses steal dormancy genes from bacteria in the human gut

Viruses steal dormancy genes from bacteria in the human gut

Wednesday, April 12, 2023

Daniel Schwartz.
Daniel Schwartz is first author on an article in mBio about the Lennon lab's recent discovery. Courtesy photo

Spore-forming bacteria that are common in the human gut can affect our nutrition and health. Most of these bacteria are beneficial, but some species in the group, like anthrax-causing Bacillus and Clostridium difficile, are pathogens that cause diarrhea, respiratory complications, inflammation, and—in some cases—death.

Daniel Schwartz is a postdoctoral researcher in the lab of Jay Lennon, a professor in the College of Arts and Sciences Department of Biology at Indiana University Bloomington. Recent studies involving phages (viruses that infect and often kill bacteria) by Schwartz and Lennon in collaboration with scientists in the lab of Kelly Wrighton at Colorado State University found that spore-forming bacteria may escape infection by entering a dormant state that protects them from virus infection. The team’s recent article published in the journal mBio describes how phages in the human gut acquire sporulation genes from bacteria that they may use to hijack their hosts.

"The bacteria we study produce dormant spores thought to play an important role in the bacteria’s colonization, persistence, and transmission," explains Schwartz. "Phages acquire bacterial genes and use them to alter host metabolism in ways that enhance phage reproduction and survival. Most auxiliary genes replace or modulate enzymes that are used by the host for nutrition or energy production; however, phage biology is affected by all aspects of the host’s physiology, including decisions that reduce metabolic activity of the bacterial cell."

An illustration of a bacterium (blue) being infected by phages (red).
Artist's rendition of phages infecting a bacterium. AdobeStock_455162791

The biologists' study suggests that phages may manipulate bacterial host genetic networks by tapping into their control elements. Their findings also suggest a mechanism by which phages can overcome the bacteria’s defensive strategy of dormancy.

Jay Lennon.
Jay Lennon. Photo by Jean Lennon

"A lot of the bacteria in our guts—the good ones and the bad ones—are susceptible to being infected by phages. Those bacteria can protect themselves from infection by going into a dormant state," Lennon explains further. "Phages may be able to get around this by 'stealing' and using genes that their bacterial hosts need for entering and exiting dormancy to defend against the phages."

The Lennon lab’s research results may help advance phage therapy, which can be used to fight infections caused by bacteria. Alternate therapies are especially critical to treat infections caused by antibiotic-resistant bacteria. The knowledge may also help in efforts to maintain healthy gut environments.

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