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  • NIH funds graduate student’s quest to understand how RNA regulation and modification contribute to successful reproduction

NIH funds graduate student’s quest to understand how RNA regulation and modification contribute to successful reproduction

Wednesday, August 31, 2022

Emily Erdmann holds a replica of a nematode.
Emily Erdmann holds a plushie of her model organism Caenorhabditis elegans, a species of nematode. Courtesy photo

Emily Erdmann is fascinated by molecular biology and genetics. In particular, she finds it interesting how the small, individual post-transcriptional regulatory events of gene expression (especially RNA-level regulation) can add up to major biological consequences.

Erdmann is a fourth-year Ph.D. student in the Genome, Cell, and Developmental Biology Graduate Program at Indiana University Bloomington and a member in the lab of Heather Hundley, an associate professor in the IU College of Arts and Sciences’ Department of Biology.

The National Institutes of Health has presented Erdmann with its Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (Parent F31). The Kirschstein-NRSA program provides promising predoctoral students with potential to develop into productive, independent research scientists the means to obtain mentored research training while conducting dissertation research. The fellowship for $97,783 will help fund Erdmann's research on ADAR function in the germline.

ADARs (Adenosine Deaminases that Act on RNA) are enzymes which can modify and regulate cellular messages in the form of RNA. ADARs can alter the expression of certain genes to help maintain the unique functions of different cell types under different conditions. Erdmann’s work specifically focuses on identifying the roles of ADARs in gene regulation in the germline, or reproductive cells. The germline is a compelling tissue for studying ADARs because RNA-level regulation of gene expression is critical in maintaining proper reproductive function.

Caenorhabditis elegans, a species of nematode.
C. elegans is a transparent nematode about 1 mm in length that lives in temperate soil environments. (Adobe Stock Image 103889066)

Erdmann uses Caenorhabditis elegans, a species of nematode, as a model system for studying the function of ADARs in the germline. She found early in her research that the majority of ADARs in adult C. elegans are present in the germline, and Erdmann has since discovered that ADARs are active in modifying hundreds of germline RNAs and affect the expression of many germline genes.

Erdmann is now focusing on understanding the functional consequences of this RNA regulation and modification to determine how they contribute to successful reproduction.

When asked why she chose to pursue her doctoral degree at IU Bloomington, Erdmann responded, “I was looking for a program and department that really understood the importance of basic biology research. I found that the faculty and students here are really passionate about what they study and have a genuine interest in what their peers study as well.”

After completing her Ph.D., Erdmann would like to continue to work in the RNA biology field and plans to pursue a career as a biomedical scientist.

Emily Erdmann wears a white lab coat as she leans against a work bench in the lab.
Emily Erdmann in the lab. Courtesy photo
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