- Postdoctoral Fellowship, University of Utah/HHMI, 2009
- Ph.D., University of Wisconsin, 2005
Heather A. Hundley
Associate Professor, Biology
Sagalowsky Professor of Biology
Director, GCDB Graduate Program
(she/her/hers)
- hahundle@indiana.edu
- 812-855-0675
- Biology Bldg. 327B
- Office Hours
Education
About Heather Hundley
Lab
Biology Bldg. 327
Hundley Lab website
Awards
- Outstanding Research Mentor, Indiana University School of Medicine-Bloomington, 2022
- Bodil Schmidt-Nielson Fund, 2021
- Salisbury Cove Research Foundation Award, 2021
- Trustee Teaching Award, IUSM
- Bergmann Prize, US-Israel Binational Science Foundation
- American Cancer Society Research Scholar Award
- Helen Hay Whitney Postdoctoral Fellowship, 2006-2009
Research
My research program takes an integrated approach using C. elegans and human cell lines to understand the biological impact of RNA editing. RNA editing is a post-transcriptional modification that alters the nucleotide sequence of RNA from that encoded by the genome. The most prevalent type of editing in humans is adenosine (A) to inosine (I) editing, with ~1,000,000 editing events identified in the human transcriptome. Brain mRNAs, some of which are required for neurogenesis, are the most edited human transcripts, and deletion of the editing machinery in lower organisms, such as C. elegans, results in behavioral defects, indicating RNA editing is required for proper neuronal development and function. In addition, alterations in editing levels have been observed in a number of neuropathological diseases—including epilepsy, depression, amyotrophic lateral sclerosis, and brain tumors. Despite the biological importance of RNA editing, the consequences of editing on normal gene expression and the mechanistic implications of aberrant editing in disease are only beginning to be dissected.
Research in the Hundley lab utilizes a combination of biochemistry, genomics, and molecular biology to both characterize the effects of editing on gene expression and elucidate molecular mechanisms that are important for regulating RNA editing. We have recently utilized next generation sequencing and molecular biology approaches to identify a major regulator of noncoding editing in C. elegans. Current efforts in the Hundley lab are focused on dissecting the molecular mechanism of this regulator and determining the conservation of this regulatory protein in human cells.
Research Areas
Chromatin, Chromosomes, and Genome Integrity
Developmental Mechanisms and Regulation in Eukaryotic Systems
Genomics and Bioinformatics
Publications
Raghava Kurup R, Oakes EK, Vadlamani P, Nwosu O, Danthi P and Hundley HA (2022) ADAR3 activates NF-kB signaling and promotes glioblastoma cell resistance to temozolomide, Scientific Reports, 2022 Aug 3;12(1):13362. doi: 10.1038/s41598-022-17559-4.
Raghava Kurup R, Oakes EK, Manning AC, Mukherjee P, Vadlamani P and Hundley HA (2022) RNA binding by ADAR3 inhibits adenosine-to-inosine editing and promotes expression of the immune response protein MAVS, JBC, 2022 Jul 15;102267. doi: 10.1016/j.jbc.2022.102267.
Erdmann EA, Abraham O and Hundley HA (2022) Caenorhabditis elegans expressing a Vitellogenin: GFP fusion protein show reduced embryo content and brood size, Micropublication Biology, 2022 Mar 1; 202210.17912/micropub.biology.000532
Mukherjee P*, Raghava Kurup R* and Hundley HA (2021) RNA immunoprecipitation to find targets of RNA modification enzymes, Methods in Enzymology: RNA Modification Enzymes, 2021;658:137-160.
Erdmann EA, Mahapatra A, Mukherjee P, Yang B and Hundley HA (2021) To protect and modify double-stranded RNA – the critical roles of ADARs in development, immunity and oncogenesis. Critical Reviews in Biochemistry and Molecular Biology, 2021 Feb; 56(1):54-87.
Rajendren S, Dhakal A, Vadlamani P, Townsend J, Deffit SN and Hundley HA (2021) Profiling neural editomes reveals a molecular mechanism to regulate RNA editing during development. Genome Research, 2021 Jan;31(1):27-39.
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