The paper “DNA-loop extruding SMC complexes can traverse one another in vivo” was featured on the cover of the journal Nature Structural & Molecular Biology.
In this paper, researchers in the Wang lab reveal an amazing variety of chromosome folding patterns that require SMC complexes to bypass each other. By combining Chromosome Conformation Capture (Hi-C), Chromatin Immunoprecipitation (ChIP-seq), Whole Genome Sequencing, and Microscopy experiments, with three-dimensional polymer simulations, this study discovered an in vivo property of the broadly conserved SMC complex that allows efficient compaction and segregation of the genome.
Wang lab members who authored the article are Zhongqing Ren (graduate student, co-first author), Xheni Karaboja (graduate student), and Xindan Wang (Assistant Professor of Biology). They were joined by Hugo Brandao (graduate student, co-first author) and Leonid Mirny (Professor of Medical Engineering and Science at MIT).