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  • Kumar awarded $1.5 million from the NEI for research on the development of the insect compound eye

Developmental biologist awarded $1.5 million from the National Eye Institute for research on the development of the insect compound eye

Wednesday, March 25, 2020

Justin Kumar.
Justin Kumar.* Photo by Sandee Milhouse

Justin P. Kumar, a professor in the Indiana University College of Arts and Sciences' Department of Biology, and his team of research associates and graduate students have been awarded $1.5 million from the National Eye Institute to investigate the role that inductive signals play in specifying the fate of the compound eye of the fruit fly, Drosophila melanogaster.

“A fundamental feature of early animal development is that molecular signals emanating from one tissue can induce fate specification and morphogenesis in a neighboring tissue,” said Professor Kumar. “This was first shown in Hydra by Ethel Browne (1909) and then later in newts by Hilde Mangold and Hans Spemann (1924). Since these seminal experiments a century ago, inductive signaling has come to be understood as a basic feature of all developing tissues and cell types.”

Professor Kumar and his team of investigators are interested in understanding how inductive signaling controls eye development.

The mammalian retina receives essential instructions from two adjacent tissues—the lens and retinal pigment epithelium (RPE). Disrupting communication between these three tissues leads to disastrous consequences for the specification and patterning of the retina in both mouse knockout models and human patients. For example, mutations in the human Pax6 gene result in several congenital disorders including Aniridia, Peter’s Anomaly, and bilateral microphthalmia. In order to understand these disorders, several researchers in Professor Kumar’s lab are focused on identifying the transcriptional networks and signaling pathways that function to induce development of the retina.

A scanning electron micrograph of the Drosophila compound eye.
Image 1: A scanning electron micrograph of the Drosophila compound eye [hi-res]. Photo courtesy of Justin Kumar

The Drosophila compound eye is a simple nervous system consisting of nearly 750 identical unit eyes (Image 1). For over a century, it has been used as a premier experimental model system to gain fundamental insights into basic principles of development.

The adult eye is derived from a monolayer epithelium called the eye-antennal disc. Overlying this tissue is another sheet of cells called the peripodial epithelium (Image 2). These two tissues are stitched together around the edges much like a closed pillowcase. Prior investigations by researchers in Gerald Schubiger and Thomas Kornberg’s labs demonstrated that cellular processes called “translumenal extensions” physically connect peripodial epithelia to imaginal discs.

More importantly, Schubiger and Kornberg observed that signaling molecules appear be transported from one tissue to another through these cellular structures (Image 3).

A drawing of the Drosophila eye-antennal disc (purple) and the overlying peripodial epithelium (blue).
Image 2: A drawing of the eye-antennal disc (purple) and the overlying peripodial epithelium (blue) [hi-res]. Illustration courtesy of Justin Kumar
A drawing of the translumenal extensions that connect the peripodial epithelium (blue) to the disc proper eye-antennal disc (purple) in Drosophila.
Image 3: A drawing of the translumenal extensions that connect the peripodial epithelium (blue) to the disc proper eye-antennal disc (purple) [hi-res]. Illustration courtesy of Justin Kumar

Researchers in Professor Kumar’s lab have demonstrated that the Pax6 transcription factor and the Transforming Growth Factor β signaling pathway function in the peripodial epithelium to regulate specification and pattern formation in the adjacent compound eye. This appears to be an exciting parallel to the development of the vertebrate eye as the orthologous molecules function in the lens and signal to the neighboring retina. The Kumar lab hopes to gain important insights into the development of the Drosophila eye as well as a more informed view of inductive signaling within the human eye. In particular, their studies will help us gain a better understanding how several congenital disorders such as Aniridia, foveal hyperplasia, ectopia pupillae, optic nerve hypoplasia, bilateral microphthalmia, congenital cataracts, and Peter’s Anomaly arise in human patients.

*Download a high-resolution version of the photo of Justin Kumar.

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