Department of Biology

Malcolm Winkler has coauthored the fourth edition of Bacterial Pathogenesis—A Molecular Approach(BPe4). Dr. Winkler is a professor in the microbiology section of the Department of Biology and adjunct core professor in the Department of Molecular and Cellular Biochemistry in the IU Bloomington College of Arts and Sciences.

The complete revision of this widely used textbook has been highly anticipated. Within a month of its publication, BPe4 became a bestseller at American Society of Microbiology (ASM) Press and became the number-one new release and bestseller in the medical microbiology section at Amazon.com.

This comprehensive edition is written for advanced-undergraduate, graduate, and professional students and other scientists interested in bacterial infection of human and animal hosts. BPe4 is already being used by Professor Winkler in his M440 Medical Microbiology course this fall.

BPe4 provides the latest information on important topics about bacterial pathogenesis, including host immune response, host microbiota, pathogen evolution, bacterial and host virulence factors, bacterial colonization and survival in hosts, bacterial toxins, virulence regulation, antibiotic action and resistance, vaccination, serious Gram-positive and -negative opportunistic pathogens, bioterrorism, and emerging diseases. Emphasized are recent cutting-edge technical advances that have revolutionized the study of bacterial pathogenesis in the short time since the last edition of the book. These advances include genetic approaches such as Tn-seq screening and CRISPR editing as well as the development of “omics” approaches such genomics, transcriptomics, proteomics, and metabolomics.

BPe4 will be distributed and promoted to students worldwide with the imprimatur of Wiley.

Dr. Winkler's coauthors on the book are lead author Professor Brenda Wilson (University of Illinois Urbana) and Professor Brian Ho (University College London).