Putnam Research Fellowship

2020 Putnam Fellow: Julie Button

Julie Button is a fifth-year graduate student in Professor Tuli Mukhopadhyay's lab. The Mukhopadhyay lab studies how alphaviruses assemble, and Julie's work is specifically focused on understanding and modulating assembly of the viral core. The formation of the viral core depends on interactions between the nucleic acid genome and capsid protein. Julie has been able to substitute a mutant capsid protein for the genome, resulting in the formation of cores without genome in vitro. This work could have applications in terms of vaccine development and/or using alphaviruses as a possible drug delivery vector. This award will provide support for Julie to move this system into cells to determine the feasibility of this system for these applications.