Professor, Biology
Director of Graduate Studies, Biology
Simon Hall 019
812-856-3633
Tuli Lab website
Fellow, American Association for the Advancement of Science, 2020
IU Trustees Teaching Award, 2013
Ever wonder how does a virus coordinate all the steps needed to make a new particle? Our lab studies the viral and host determinants required for alphavirus assembly and spread. Alphaviruses are arboviruses—they are transmitted from a mosquito to a vertebrate—so we focus on how the assembly determinants are conserved or differ in these two hosts. We use a variety of approaches to study assembly including viral and host genetics, cell biology, biochemistry, and structural biology. For details, see our lab website.
Roger, K.J., Jones-Burrage, S. E., Maury, W., and Mukhopadhyay, S. (2020) TF protein of Sindbis virus antagonizes host type I interferon responses in a palmitoylation-dependent manner. Virology 542:63-70.
Harrington, H. R., Zimmer, M. H., Chamness, L. M., Nash, V., Penn, W. D., Miller III, T. F. Mukhopadhyay, S., and Schlebach, J. S. (2020) Cotranslational Folding Stimulates Programmed Ribosomal Frameshiting in the Alphavirus Structural Prolyprotein. J. Biol. Chem. 295(20):6798-6808. **Selected for Editor’s choice
Mastrodomenico, V., Esin, J. J., Qazi, S. A., Khomutov, M. A., Ivanov, A. V., Mukhopadhyay, S., and Mounce, B.C. (2020) Virion-associated spermidine transmits with Rift Valley fever virus to maintain infectivity and promote entry. ACS Infect. Dis. 6:2490-2501. **Selected for Editor’s choice
Penn, W. D., Harrington, H. R., Schelbach, J. P. and Mukhopadhyay, S. (2020) Regulators of viral frameshifting: More than RNA influences translation events. Ann. Rev. Virol. 7:219-238.
Button, J. M., Qazi, S. A., Wang, J. C., and Mukhopadhyay, S. (2020) Revisiting an old friend: new findings in Alphavirus structure and assembly. Curr. Opin. Virol. 45:25-33.
Button, J.M. and Mukhopadhyay, S. (2020) Removing the Polyanionic Cargo Requirement for Assembly of Alphavirus Core-Like Particles to Make an Empty Alphavirus Core. Viruses. 12, 846.
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