- Postdoctoral Fellow, Harvard Medical School, Department of Microbiology and Immunobiology, 2011-2018
- Ph.D., Biomedical Sciences, National Autonomous University of Mexico, 2007-2011
Cristina Landeta
Assistant Professor, Biology
- clandeta@iu.edu
- 812-856-3473
- Biology Bldg. 418A
- Office Hours
Education
Industry experience
Strain Engineer Scientist, enEvolv, The Genome Engineering Company, 2018-2019
About Cristina Landeta
Lab
Biology Bldg. 418
812-856-3013
Landeta Lab website
Research
The goal of my research is to enable the systematic identification of substrates of the disulfide bond formation pathways of two human pathogens, Pseudomonas aeruginosa and Mycobacterium tuberculosis as well as to characterize the pathways that introduce disulfide bonds in Clostridia and in the gut microbiome using E. coli tools. We will determine whether microorganisms in the gut microbiome modulate the virulence/growth of other microorganisms by inhibiting their disulfide bond formation pathways targeting either DsbB, VKOR or DsbA homologues and we will investigate the impact of the bacterial and archaeal disulfide bond formation pathways in the gut microbiome by in situ identification of the proteins that are secreted and disulfide bonded to the extracellular milieu.
Research areas
Publications
Landeta C., Laura McPartland, Ngoc Q. Tran, Brian M. Meehan, YiFan Zhang, Zaidi Tanweer, Shoko Minami, Jeremy Rock, Eric J. Rubin, Steve Lory, Gerald Pier, Dana Boyd, and Jon Beckwith. Inhibition of Pseudomonas aeruginosa and Mycobacterium tuberculosis disulfide bond forming enzymes. Mol. Microb. 111(4): 918-937.
Landeta C., Boyd D., and Beckwith J. 2018. Disulfide bond formation in prokaryotes. Nature Microbiol. 3:270-280.
Landeta C., Meehan B. M., McPartland L., Ingendahl L., Hatahet F., Tran N.Q., Boyd D., and Beckwith J. 2017. Inhibition of virulence-promoting disulfide bond formation enzyme DsbB is blocked by mutating residues in two distinct regions. J. Biol. Chem. 292(16) 6529–6541.
Landeta C., et al., 2015. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. Nat. Chem. Biol. 11 (4): 292-298.
Landeta C., A. Dávalos, M. A. Cevallos, O. Geiger, S. Brom, and D. Romero. 2011. Plasmids with a chromosome-like role in Rhizobia. J. Bacteriol. 193: 1317- 1326.
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