Cristina Landeta

Cristina Landeta

Assistant Professor, Biology

Education

  • Postdoctoral Fellow, Harvard Medical School, Department of Microbiology and Immunobiology, 2011-2018
  • Ph.D., Biomedical Sciences, National Autonomous University of Mexico, 2007-2011

Publications

*Corresponding author 
#Equal contribution

Collins R., Andréani J., Chavez D., Rusch D. B., Boyd D, Colson P., LaScola B., Landeta C*. Giant viruses encode vitamin K–based redox modules for lipid modification. bioRxiv 2026.03.26.714578; https://doi.org/10.64898/2026.03.26.714578. Accepted at PNAS.

Antonika C., Mendoza J., Landeta C*. Disulfide bond-forming enzymes in clostridial species. 2025. Microbiology.  . Research highlight here

Mejia-Santana, Collins R., Doud E.H., Landeta C*. Disulfide bonds are critical for stabilizing cell division, cell envelope biogenesis and antibiotic resistance proteins in mycobacteria. 2025. mBio 0:e01083-25.https://journals.asm.org/doi/10.1128/mbio.01083-25. bioRxiv 2025.01.27.635063.

Chavez D.#, Amarquaye G. N.#, Mejia-Santana A., Dyotima, Ryan K., Zeng L.,  Landeta C*. Warfarin analogs target disulfide bond-forming enzymes and suggest a residue important for quinone and coumarin binding. 2024. J Biol Chem. 2024 Jun;300(6):107383.https://www.jbc.org/article/S0021-9258(24)01884-2/fulltext.

Dyotima#, Abulaila S.#, Mendoza J., Landeta  C*. Development of a sensor for disulfide bond formation in diverse bacteria. 2024. J. Bacteriol. Mar 13. https://doi.org/10.1128/jb.00433-23

Antibiotic potentiation and inhibition of cross-resistance in pathogens associated with cystic fibrosis. Kadeřábková N., Furniss R. C. D., Maslova E., Eisaiankhongi L., Bernal P., Filloux A., Landeta C, Gonzalez D, McCarthy R. R., Mavridou D. A. I. 2023. eLife12:RP91082. https://doi.org/10.7554/eLife.91082.1

Landeta  C.*, and Mejia-Santana  A. Union Is Strength: Target-Based and Whole-Cell High-Throughput Screens in Antibacterial Discovery. 2022. J. Bacteriol. Apr 19;204(4):e0047721. doi: 10.1128/JB.00477-21

Prior to IU

Landeta C., McPartland L., Tran N. Q., Meehan B. M., Zhang Y., Tanweer Z., Wakabayashi S., Rock J., Rubin E. J., Lory S., Pier G., Dana Boyd, and Beckwith J. Inhibitors of Pseudomonas aeruginosa and Mycobacterium tuberculosis disulfide bond forming enzymes. 2019. Mol. Microb 111(4):918-937. PDF

Ke N., Landeta C., Wang X., Boyd D., Eser M., Beckwith J. Identification of the thioredoxin partner of VKOR in mycobacterial disulfide bond formation. 2018. J Bacteriol. 200(16): e00137-18. PDF

Landeta C., Boyd D., and Beckwith J. Disulfide bond formation in prokaryotes. 2018. Nature Microbiol. 3:270-280. PDF

Hibender S.#, Landeta C.#, Berkmen M., Beckwith J., and Boyd D. Aeropyrum pernix Membrane Protein VKOR Promotes Protein Disulfide Bond Formation in Two Subcellular Compartments. 2017. Microbiology 163:1864-1879. PDF

Meehan B. M., Landeta C., Boyd D., Beckwith J. The Disulfide Bond Formation Pathway is Essential for Anaerobic Growth of Escherichia coli. 2017. J. Bacteriol. 199(16): e00120-17. PDF

Landeta C., Meehan B. M., McPartland L., Ingendahl L., Hatahet F., Tran N.Q., Boyd D., and Beckwith J. Inhibition of virulence-promoting disulfide bond formation enzyme DsbB is blocked by mutating residues in two distinct regions. 2017. J. Biol. Chem. 292(16):6529–6541. PDF

Meehan B. M., Landeta C., Boyd D., and Beckwith J. 2017. The Essential Cell Division Protein FtsN Contains a Critical Disulfide Bond in a Non-essential Domain. Mol. Microbiol. Mol. Microbiology. 103 (3):413-422. PDF

Landeta C.#, Blazyk J.L.#, Hatahet F.#, Meehan B.M., Eser M., Myrick A., Bronstain L., Minami S., Arnold H., Ke N., Rubin E.J., Furie B.C. Furie B., Beckwith J., Dutton R., and Boyd D. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. 2015. Nat. Chem. Biol. 11 (4): 292-298. PDF

Landeta C., Dávalos A., Cevallos M. A., Geiger O., Brom S., and Romero D.. Plasmids with a chromosome-like role in Rhizobia. 2011. J. Bacteriol. 193: 1317- 1326. PDF