David Kehoe

David Kehoe

Professor, Biology

Education

  • NSF Postdoctoral Fellow, Carnegie Institution, Stanford University, 1993
  • Ph.D., University of California, Los Angeles, 1992

Publications

Grébert, T., Nguyen, A. A., Pokhrel, S., Joseph, K. L., Ratin, M., Dufour, L., Chen, B., Haney, A. M., Karty, J. A., Trinidad, J., Garczarek, L., Schluchter, W. M., Kehoe, D. M., and F. Partensky. 2020. Molecular basis of an alternative dual-enzyme system for light color acclimation of marine Synechococcus cyanobacteria. Proceedings of the National Academy of Sciences USA. In Press.

Nguyen, A. A., Joseph, K. L., Bussell, A. N., Pokhrel, S., Karty, J. A., Kronfel, C. M., Kehoe, D. M., and W. M. Schluchter. 2020. CpeT is the phycoerythrobilin lyase for Cys-165 on b phycoerythrin from Fremyella diplosiphon and the chaperone-like protein CpeZ greatly improves its activity. Biochimica Biophysica Acta—Bioenergetics. 1861: 148284

Kronfel, C. M., Biswas, A., Frick, J. P., Gutu, A., Blensdorf, T., Karty, J. A., Kehoe, D. M., and W. M. Schluchter. 2020. Biogenesis of phycoerythrin. I. Defining the roles of the phycoerythrobilin lyase CpeY and the chaperone-like protein CpeZ in Fremyella diplosiphon. Biochimica Biophysica Acta—Bioenergetics, 1860: 549-561. https://doi.org/10.1016/j.bbabio.2019.06.001

D. M. Kehoe. 2020. Phycobilisome Antennae and Chromatic Acclimation. Encyclopedia of Biochemistry. R. Blankenship, Ed. Elsevier Publishers, 3rd Edition

Sanfilippo, J. E., Garczarek, L., Partensky, F., and D. M. Kehoe. 2019. Chromatic acclimation in cyanobacteria: A diverse and widespread process for optimizing photosynthesis. Annual Review of Microbiology, 73:407-433.

Kronfel, C. M., Hernandez, C. V., Hernandez, L. S., Gutu, A., Karty, J. A., Boutaghou, M. N., Kehoe, D. M., Cole, R. B., and W. M. Schluchter. 2019. Biogenesis of phycoerythrin. II. CpeF is the bilin lyase that ligates the doubly-linked phycoerythrobilin on β-phycoerythrin in Fremyella diplosiphon. Journal of Biological Chemistry, 294: 3987-3999

Sanfilippo, J. E., Nguyen, A. A., Garczarek, L., Karty, J. A., Pokhrel, S., Strnat, J. A., Partensky, F., Schluchter, W. M., and D. M. Kehoe. 2019. Interplay between differentially expressed enzymes controls light color acclimation in marine Synechococcus. Proceedings of the National Academy of Sciences USA, 116: 6457-6462

Haney, A. M. and D. M. Kehoe. 2019. Microbe of the month: Fremyella diplosiphon. Trends in Microbiology, 27: 562-563 (Note: This manuscript was featured on the cover of the journal.)

Wiltbank, L. B. and D. M. Kehoe. 2019. Diverse light responses of cyanobacteria mediated by phytochrome superfamily photoreceptors. Nature Reviews Microbiology, 17: 37-50

Grébert, T., Doré, H., Partensky, F., Farrant, G. K., Boss, E., Picheral, M., Guidi, L., Pesant, S., Scanlan, D. J., Wincker, P., Acinas, S. G., Kehoe, D. M. and L. Garczarek. 2018. Light color acclimation: a key process in the global ocean distribution of Synechococcus cyanobacteria. Proceedings of the National Academy of Sciences USA. 115 E2010-E2019;doi.org/10.1073/pnas.1717069115

Mahmoud, R. M., Sanfilippo, J. E., Nguyen, A. A., Strnat, J. A., Partensky, F., Garczarek, L., El-Kassem, N. A., Kehoe, D. M. and Schluchter, W. M. 2017. Adaptation to blue light in marine Synechococcus requires MpeU, an enzyme with similarity to phycoerythrobilin lyase isomerases. Frontiers in Microbiology 8: 243.

Sanfilippo, J. E., Nguyen, A. A., Karty, J. A., Shukla, A., Schluchter, W. A., Garczarek, L., Partensky, F. and D. M. Kehoe. 2016. A self-regulating genomic island encoding tandem regulators confers chromatic acclimation to marine Synechococcus. Proceedings of the National Academy of Sciences USA. 113(21): 6077-6082.

Wiltbank, L. B. and D. M. Kehoe. 2016. Two cyanobacterial photoreceptors regulate photosynthetic light harvesting by sensing teal, green, yellow and red light. mBio. (1): e02130-15.

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