Karen Bush

Karen Bush

Professor of Practice Emerita, Biology (Biotechnology)



The Bush lab is not accepting any new students or postdocs.


  • Postdoctoral Fellow, University of California, Santa Barbara, 1970-1971
  • Ph.D., Indiana University Bloomington, 1970
  • B.A., Monmouth College (IL), 1965

Representative publications

Bush K, Bradford PA. 2019. Interplay between β-lactamases and new β-lactamase inhibitors. Nature Reviews Microbiology 17:295-306. doi.org/10.1038/s41579-019-0159-8

Bush K. 2018. Past and present perspectives on β-lactamases. Antimicrobial Agents & Chemotherapy 62:e01076-18. dx.doi.org/10.1128/AAC.01076-18

Bush K. A Meandering Path from Biochemist to Microbiologist. ACS Infectious Diseases. 2018-12-04. DOI: 10.1021/acsinfecdis.8b00261.

Zhang, Y., A. Kashikar, C. A. Brown, G. Denys, and K. Bush. 2017. An unusual E. coli PBP3 insertion sequence identified from a collection of carbapenem-resistant Enterobacteriaceae (CRE) tested in vitro with ceftazidime-, ceftaroline- or aztreonam-avibactam combinations. Antimicrob. Agents Chemother. August 2017 61:e00389-17; Accepted manuscript posted online 30 May 2017, doi:10.1128/AAC.00389-17.

Kao, C., X. Lin, G. Yi, Y. Zhang, D. A. Rowe-Magnus, and K Bush. 2016. Cathelicidin antimicrobial peptides with reduced activation of Toll-like receptor signaling have potent bactericidal activity against colistin-resistant bacteria. mBio 7(5):e01418-16. doi:10.1128/mBio.01418-16.

Estabrook, M., M. B. Bussell, S. L. Clugston and K. Bush. 2014. In vitro activity of ceftolozane-tazobactam as determined by broth dilution and agar diffusion assays against recent U.S. Escherichia coli isolates from 2010 to 2011 carrying CTX-M-Type Extended-Spectrum β-Lactamases. J. Clin. Microbiol. 52:4049-4052.

Bush, K., M. Pannell, J. L. Lock, A. M. Queenan, J. H. Jorgensen, R. M. Lee, J. S. Lewis, and D. Jarrett. 2013. Detection systems for carbapenemase gene identification should include the SME serine carbapenemase. Intl. J. Antimicrob. Agents 41:1-4.

Yigit, H., A. M. Queenan, G. J. Anderson, A. Domenech-Sanchez, J. W. Biddle, C. D. Steward, S. Alberti, K. Bush and F. C. Tenover. 2001. Characterization of a novel carbapenem hydrolyzing β-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae. Antimicrob. Agents Chemother. 45:1151-1161.

Bush, K.,G. A. Jacoby and A. A. Medeiros. 1995. A functional classification scheme for β-lactamases. Antimicrob. Agents Chemother. 39:1211-1233

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